Specialty Physician Complete Packaged Procedure. Plasmapheresis is a blood purification procedure used to treat several autoimmune diseases. It is also known as therapeutic plasma exchange. The basic procedure consists of removal of blood, separation of blood cells from plasma, and return of these blood cells to the body’s circulation, diluted with fresh plasma or a substitute. One Treatment cost includes the facility fee, physician’s fee, related medical procedures and drugs required to administer the plan of care. Not included are diagnostic studies, consultations with additional specialists and cost of complication management; travel, food and lodging.